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[Average] GENERALLY AVOID: Coadministration with grapefruit juice may well marginally boost the oral bioavailability and hold off the onset of action of sildenafil.

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If the NO/cGMP pathway is activated, as takes place with sexual stimulation, inhibition of PDE5 by sildenafil results in elevated corpus cavernosum levels of cGMP . Consequently sexual stimulation is needed to ensure that sildenafil to produce its intended advantageous pharmacological consequences .

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